Direct dISF sampling reveals what pharmacokinetics models can’t. It provides access to free-fraction drug concentrations in the dermis and validates - or challenges - PK models used to determine dosing.


Customer case:
12 PELSA systems were used in a Phase I pharmacokinetics study to determine skin tissue concentrations of an oral medication. Direct dISF sampling enabled highly accurate measurement of tissue drug concentrations.

Investigate stress and reproductive hormone levels using dermal interstitial fluid sampling. Both baseline levels and hormone dynamics can be mapped using dISF sampling.

Customer case:
Together with ETH, University of Zurich and the Department of Endocrinology at the University of Sao Paolo, one of the largest studies investigating cortisol levels in endocrinology disorders is currently comparing hormone levels between blood and dermal ISF sampled with PELSA.

Measure inflammation where it occurs: PELSA enables direct, repeat sampling of dISF at the site of inflammation, capturing localized biomarker dynamics that may be diluted or undetectable in blood.

Customer case:
The Institute of Allergology at Charité – Universitätsmedizin Berlin utilizes PELSA daily as they map the underlying mechanisms of inflammatory skin diseases such as urticaria, psoriasis, and atopic dermatitis.

Sampling dISF in real time enables repeat access to cardiovascular biomarkers, opening a dynamic new window into cardiovascular health — paving the way for continuous monitoring, early risk detection, and personalized intervention.

Customer case:
The DIGIPREDICT study measured cardiovascular biomarker levels in dISF before, directly after, and 30 mins after a cardiac stress test. Assessing nearly 100 markers, the dISF extracted at each timepoint with PELSA reflected dynamics of the stress test.